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Can you take Zoloft and nexium together? Top Answer. Kenneth Koe, an inventor of Zoloft, the antidepressant that has helped tens of millions of people since it was introduced a quarter-century ago, died on … Nexium and Prilosec are heartburn medications — more specifically Proton Pump Inhibitors (PPI) — manufactured by AstraZeneca Pharmaceuticals.Nexium, whose active ingredient is Esomeprazole, is prescription medicine that is principally used to treat GERD and Zollinger-Ellison Syndrome. It says dont take other meds with it. Nexium is a very unstable drug, that even if it entered milk, would be destroyed in the infant's stomach. Prozac and Zoloft are two types of antidepressant. Zoloft (sertraline) is a type of antidepressant medication commonly used to treat depression and anxiety. If it's nearly time of the next dose simply cut it and return to your own regular dosage schedule. 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Nexium (esomeprazole) is a proton pump inhibitor (PPI) used to treat stomach and duodenal ulcers, gastroesophageal reflux disease (GERD), and the Zollinger-Ellison syndrome. Answer. Mmol l. Abnormal gcs or avpu score. Consequently their dose should be corrected. The same interaction doesn't occur with Zoloft and Nexium. Formulation. Nexium is an hour before eating also. Nexium may slow metabolism of medicines that are such: citalopram, diazepam, clomipramine, phenytoin, imipramine down. Wiki User Answered . I have also had Dilaudid multiple times in the past (both IV in the hospital and pills) for chronic kidney stones (which are more painful than childbirth) and it’s CRAZY to prescribe it for dental surgery. Plus, it's not "dangerous," but it's something that needs to be watched to make sure everything is being metabolized properly. Does Nexium Capsule,Delayed Release (Enteric Coated) Interact with other Medications? 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